Dyslipidemia induced by high-fat diet

Fenugreek Trigonella foenum-graecum L. Fat-pad Analysis At the end of the eleventh week, animals were decapitated between Six rats were kept on the standard chow diet control group.

Preadipocytes were incubated with RMR extracts or lovastatin at the indicated concentrations for 24 and 48 h. Protein bands were stained with Coomassie Brilliant Blue R in methanol-acetic acid-water 5: On day 8, the cells were harvested to determine triglyceride accumulation—a marker of dyslipidemia induced by high-fat diet.

GSPE exert some of these effects by a pathway that involves overexpressing the nuclear receptor small heterodimer partner SHP and repressing the transcription factor sterol regulatory element-binding protein 1 SREBP1. The mixture was vortexed and diluted with water to a final volume of 5 mL.

Rats were fed a standard chow control diet c or the chow diet supplemented with butter HFlovastatin L0.

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The vehicle control was 0. This expression profile in the liver of HFD rats suggests active TG synthesis and VLDL assembling as well as impaired fatty acid oxidation, which is consistent with the fatty liver, hypercholesterolemia and hypertriglyceridemia present in these animals.

The cafeteria diet is a feeding regime in which animals are offered a choice of several palatable food items of varied composition, appearance and texture in addition to their normal chow diet. The following parameters were measured: The viable cell ratios were calculated according to the following formula: It appears that the increased size rather than number of adipocytes contributed to the increase in fat mass in the HF group.

However, looking to structural similarity with the presently known Melanocortin-4 MC-4 agonists, involvement of MC-4 receptors in its activity can be guessed. In the animal study, 0.

The collected fat was weighed immediately and compared with the other groups. Kota V.

When adipocytes reach a critical size threshold, preadipocytes in close proximity to the adipocytes will respond to positive energy balance by proliferating and then differentiating into adipocytes to store the excess energy. Proliferation assay Preconfluent 3T3-L1 preadipocytes were seeded in well dishes at a density of 7.

In addition, extracts of RMR suppressed the proliferation and differentiation in 3T3-L1 preadipocytes, which might have contributed to the inhibition of new adipocyte formation or hyperplasia in adipose tissue.

Design and measurements: Glycerol was determined enzymatically from the supernatant by using a Randox kit. The administration of proanthocyanidins normalized plasma triglyceride and LDL-cholesterol both parameters significantly increased with the HFD but tended to decrease hypercholesterolemia and fatty liver.

In addition, liver and uterine WAT lipogenic enzyme fatty acid synthetase FAS and glucosephosphate dehydrogenase G6PD activities were restored towards normal levels.

Weight and cellularity of adipose tissues in male Wistar rats. However, GSPE did not correct obesity, and only slightly reduced hypercholesterolemia and fatty liver. The degree of the linear relationship between two variables was measured by Pearson's correlation coefficient.

However, the water extracts of RMR also showed an inhibitory effect on 3T3-L1 preadipocyte proliferation, suggesting that components of RMR other than monacolin K may also have antiproliferative activity against preadipocytes.

In the face of this unmet medical need, there is requirement of new potential antiobesity drug to combat this syndrome. Institute of Pharm. Grape seed proanthocyanidin extracts GSPE reduce foam cells, 9 prevent aortic atherosclerosis 10 from developing in a hamster atherosclerosis model, decrease oxidized LDL in hypercholesterolemic humans 9 and improve endothelial function by modifying NO production.

Lipolysis activity was determined by measuring the amount of glycerol released into the incubation medium GY; Randox Inc. On the basis of the results, we suggest that the lipolytic components of RMR may be hydrophilic and thus exist mainly in water extracts, which is practical at physiological concentrations.

Duncan's test was used for the statistical analysis. However, serum insulin levels were significantly greater in the HF group than in the control group.Sep 16,  · Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet Skip to main content Thank you for visiting elbfrollein.com by: Nov 03,  · In this study, we examined the role of miR in the cardiac and metabolic alterations promoted by high fat (HF) diet.

We found that loss of miR attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be elbfrollein.com by: 3.

Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats

nutrients Article Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway Erdong Yuan 1 ID, Xuefei Duan 1, Limin Xiang 2, Jiaoyan Ren 1,3, Xingfei Lai 2, Qiuhua Li 2, Lingli Sun 2,* and Shili Sun 2,* 1 School of Food Science and Engineering, South China University of Technology, GuangzhouChina;Cited by: 6.

Objective. We previously found that lipoic acid (LA) improved high-fat diet (HFD)–induced dyslipidemia in rats. To elucidate the molecular mechanisms of that effect, we carried out experiments aimed at analyzing biochemical parameters and gene expression elbfrollein.com by: Jul 07,  · GSPE treatment prevents dyslipidemia induced by high-fat diet.

The body weight of rats fed with an HFD was significantly higher (approximately 40%) than those in the control group ().After 13 Cited by: Male Sprague Dawley rats were fed high-fat diet (HFD) for the first eight weeks, to develop obesity-induced dyslipidemia.

Later on piperine (40 mg / kg) and sibutramine (5 mg / kg) were administered for three weeks along with the continuation of HFD to two separate groups, which served as the test.

Dyslipidemia induced by high-fat diet
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